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A Competition for the position of post-doc at the at the Faculty of Chemistry in the project: “Molecular geometry – pre- and post-synthetically modified shape-persistent macrocycles of a great chiroptical response, for molecular tectonics and chirality sensing”
contract number: UMO-2023/49/B/ST5/00574
In this project, we intend to prove that intentionally designed selected groups of chiral polyaza macro- and gigantocyclic compounds of periodical and symmetrical structure may act as tunable and highly responsible sensors and tectons. The molecular and supramolecular systems designed and studied within this proposal will resemble macroscopic geometric objects such as figures, solids, and helixes of natural origin. The mechanism of action of these compounds will be based on some fundamental processes, namely, molecular recognition, enantiodiscrimination, aggregation, and assembly. We intend to demonstrate the versatility of macro- and gigantocyclic (over 50-membered) derivatives as molecular receptors and chirality sensors. The change of the size of the internal cavity and/or the possibility of formation of the receptor pocket allows for selective encapsulations of guests. Using chiral but conjugated macrocycles of planar or tubular structure for recognition and in tectonics will be an important novelty.
The candidate will be involved in:
- Synthesizing conjugated macrocycles containing additional chirality elements on the periphery of the ring, mainly derivatives of terephthalaldehyde or diaminobenzene.
- The development of catalytic and convenient methods of post-synthetic modifications of polyamines or polyamines, with special emphasis on synthesizing polyamide derivatives of macrocyclic polyamines.
- Conducting independent searches of scientific literature.
- Active participation in carrying advanced syntheses and experiments, discussing results, and preparing manuscripts.
- Designing new chiral materials with predefined properties.
Requirements
The competition is open to individuals who meet the requirements.
- Specified in Article 113 of the Law on Higher Education and Science of 20 July 2018.
- Appendix No. 2 to the Regulations on the allocation of funds for the implementation of tasks financed by the National Science Center in the field of research projects, as defined by Resolution of the NCN Council No. 23/2023 of February 16, 2023.
- PhD degree in chemistry or a related field, obtained not later than 7 years before submitting the applications
Specific Requirements
- Knowledge and skills in catalysis and synthesis.
- Authorship or co-authorship of scientific publications in chemistry and catalysis.
- Knowledge of analytical methods typical of organic chemistry and catalysis (NMR, FT IR, MS).
- Presentations at national and foreign scientific conferences.
- At least one year of scientific internship in another scientific unit, outside the country of residence of the applicant.
Additional advantages will be:
- Experience in material engineering.
- Ability to work in a group, independence, creativity, motivation.
- Experience as the role of manager or contractor in research projects.
Language:
ENGLISH, level: Excellent
- an atmosphere of respect and cooperation
- supporting employees with disabilities
- flexible working hours
- funding for language learning
- co-financing of training and courses
- additional days off for education
- life insurance
- pension plan
- savings and investment fund
- preferential loans
- additional social benefits
- leisure-time funding
- subsidizing children's vacations
- "13th" salary
- Scientific achievements documented by publications in the field of research topics specified in the competition requirements (0-20 points).
- Completed scientific internships, participation in conferences, scientific seminars, workshops, trainings (0-20 points).
- Participation in research projects (0-10 points).
Required documents:
- Application form/letter of the candidate.
- Curriculum Vitae.
- Diplomas or certificates issued by colleges and universities attesting to education and degrees or titles held (in case of academic degrees obtained abroad - the documents must meet the equivalence criteria set out in Article 328 of the Act of 20 July 2018 Law on Higher Education and Science.
- Information on the Applicant’s research, teaching, and organizational achievements.
- Short description of one, the most important scientific achievement (max. 2 A4 format pages, font: Calibri 11, single interline).
- Consent to the processing of personal data as follows : In accordance with Article 6 (1) (a) of the General Data Protection Regulation of 27 April 2016. (OJ EU L 119/1 of 4 May 2016) I consent to the processing of personal data other than: first name, (first names) and surname; parents' first names; date of birth; place of residence (mailing address); education; previous employment history, included in my job offer for the purpose of the current recruitment.";
Type of an employment contract and expected duration of employment:
Fixed-term employment contract from 01.02.2025 - 31.01.2026
WHERE TO APPLY?
email: marcin.kwit@amu.edu.pl
DEADLINE: 14th December 2024 by 6:00 a.m. (CET/Warsaw Time)
Contact
We are seeking for a motivated and virology-interested researcher for a post-doc position in the Department of Molecular Virology in the OPUS project funded by the National Science Centre (the project description can be found at https://projekty.ncn.gov.pl/index.php?projekt_id=591109).
The selected candidate will investigate novel regulatory mechanisms involved in the HPV infectious entry mechanism, with a particular focus on post-translational modifications, specifically ubiquitination, of the major capsid protein L1. This research aims to enhance understanding of the HPV life cycle and identify potential new approaches for preventing infection. The ubiquitin-conjugating system plays an essential role in the regulation of many cellular pathways and infection of different viruses. Targeting the components of the ubiquitin-conjugative system by small molecular regulators could provide a unique opportunity for the development of therapeutics for the treatment of HPV infection, which is currently dismal.
The research will include standard biochemical and molecular biology methods upgraded in advanced methods such as live-cell imaging, high-throughput screening (HTS), pseudoviral particles (PsVs) production, and 3D organotypic raft culture models. Previous experience with all these methods is not required, as the candidate will have the opportunity to develop these skills through collaborations with leading research institutions in France, Slovenia, and Italy.
The laboratory is based at the Faculty of Biology, Adam Mickiewicz University in Poznań, one of a top research institution in Poland. Our team is composed of young, dynamic scientists working in a collaborative and respectful environment that emphasizes innovation, professional development, and teamwork. We are committed to creating a supportive, productive, and growth-oriented workplace.
Requirements
Sklills/Qualifications
PhD degree in biology, biochemistry, biotechnology or related (in accordance with the Polish National Science Center Regulations, under the OPUS 25 call, the applicant had to have been awarded a PhD degree in an institution other than AMU or had completed at least 10 months, continuous and documented foreign postdoctoral fellowship, moreover, the obligatory formal criterion for admission to the call is to be awarded a PhD degree in the year of employment in the project or within 7 years before 1 January of the year employment in the project).
Candidates must meet the eligibility requirements laid down in the NCN regulations for the OPUS 25 call: https://www.ncn.gov.pl/sites/default/files/pliki/koszty_edycja_51_pl.pdf
Also:
- Strong knowledge and expertise in biochemistry, proteomics, molecular biology, and cell biology.
- Proficiency in fundamental laboratory techniques, such as nucleic acid and protein isolation, PCR, and Western blot.
- Experience with mammalian cell cultures will be considered a valuable asset.
- Experience in working with a fluorescence and/or confocal microscope will be highly appreciated
- The candidate should demonstrate passion for learning, the ability to work independently and as part of a team, as well as strong organizational and communication skills.
LANGUAGE ENGLISH, level EXCELLENT
- an atmosphere of respect and cooperation
- supporting employees with disabilities
- flexible working hours
- funding for language learning
- co-financing of training and courses
- additional days off for education
- life insurance
- pension plan
- savings and investment fund
- preferential loans
- additional social benefits
- leisure-time funding
- subsidizing children's vacations
- "13th" salary
- a creative, innovative and friendly work environment
- Technical Competence – The candidate’s expertise and how well it matches the requirements of the position.
- Scientific Achievements – This includes publications, awards, grants, and other significant accomplishments.
- Experience – The range and depth of the candidate’s experience, particularly in interdisciplinary work, mobility, and adaptability.
- Soft Skills – Including leadership, motivation, teamwork, and communication abilities.
Candidates will be evaluated according to their:
WHERE TO APPLY?
email: justyna.broniarczyk@amu.edu.pl
Application Deadline: 31st December 2024 by 11:59 p.m. (CET/Warsaw Time)