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Project leader: Prof. Krzysztof Sobczak
Project title: Pathogenesis driven by RNAs with expansion of trinucleotide repeats: mechanisms and therapeutic strategies
Project is carried out within the MAESTRO programme of the National Science Center.
Position for PostDoc available at the Department of Gene Expression, Institute of Molecular Biology and Biotechnology (IMBB), Faculty of Biology, Adam Mickiewicz University in Poznań (AMU). AMU is the largest academic center in Poznań and one of the best research centers in Poland (ID-UB status).
We are looking for people interested in research work in a team dealing with research related to human molecular genetics, under the direction of Professor Krzysztof Sobczak. The team's interests focus primarily on the study of the molecular basis and the development of experimental therapy for selected neurodegenerative diseases associated with trinucleotide repeat expansion (myotonic dystrophies - DM, and fragile X-associated syndromes - FXS and FXTAS).
DM1 is an autosomal dominant disorder caused by CTG repeat expansion in the 3'-UTR of the DMPK gene. The DMPK transcript contains extended CUG repeats (CUGexp) and is retained in the nucleus in the form of nucleoprotein clusters (foci). This nuclear retention of the DMPK transcript is in part a consequence of the interaction of CUGexp RNA with RNA binding proteins, such as splicing factors belonging to the Muscleblind-like protein (MBNL) family. The binding of hundreds of MBNL proteins to a single CUGexp RNA results in their functional deficiency and disruption of alternative splicing, a process normally regulated by these proteins.
In our research, we focus on a deeper understanding of some aspects of the molecular basis of DM (CUGexp) and FXTAS (CGGexp), especially those related to metabolism of toxic RNAs, the functions of individual splicing factors, and disturbances in non-canonical translation occurring directly on the sequence of trinucleotide repeats (the so-called RAN translation). We also focus on the development of therapeutic approaches using antisense oligonucleotides (ASOs) and small compounds that prevent the interaction of CUGexp (DM) and CGGexp (FXTAS) RNAs with proteins.
Basic duties:
- Conducting experiments explaining the mechanisms of RNA recognition by MBNL proteins and the regulation of alternative splicing by these proteins based on whole transcriptome approaches.
- Conducting experiments explaining the mechanisms of RAN translation of CGGexp in the FMR1 mRNA – cell-base experiments and whole transcriptome approaches.
- Experimental therapy of DM1 and FXTAS with the use of ASO and small compounds both in vitro and in animal models of these diseases.
- Participation in the preparation of publications.
Requirements
- The successful candidate must have a Ph.D. degree in biology, biochemistry, chemistry, genetics, computational biology or related life science field (in case of academic degrees obtained abroad - the documents must meet the equivalence criteria set out in in Article 328 of the Act of 20 July 2018 Law on Higher Education and Science (Journal of Laws 2023, item 742 i.e.);
- Proven record of productivity and publications in high-impact journals;
Language: ENGLISH, level: GOOD
Additional Information
- an atmosphere of respect and cooperation
- supporting employees with disabilities
- flexible working hours
- funding for language learning
- co-financing of training and courses
- additional days off for education
- life insurance
- pension plan
- savings and investment fund
- preferential loans
- additional social benefits
- leisure-time funding
- subsidizing children's vacations
- "13th" salar
- Obtaining a doctoral degree in an entity other than the entity where employment in this position is planned;
- Employment for a period of not less than 6 months;
- During the period of receiving this remuneration, the employed person will not receive any other remuneration from the funds allocated as direct costs from research projects financed under NCN calls;
- During the period of receiving this remuneration, the employed person will not receive remuneration from another employer under an employment contract, including from an employer based outside Poland.
- Required documents:
- Application form/letter of the candidate;
- Professional CV including scientific achievements;
- Diplomas or certificates issued by colleges and universities attesting to education and degrees or titles held (in case of academic degrees obtained abroad - the documents must meet the equivalence criteria set out in Article 328 of the Act of 20 July 2018 Law on Higher Education and Science (Journal of Laws of 2023, item 742 i.e.; Polish: Dziennik Ustaw 2023 poz. 742 tj.);
- Information on the Applicant’s research, teaching and organizational achievements;
- List of publications;
- Letter summarizing previous work, experience and future interests;
- Contact information for two professional references;
- Candidates will be selected through an open competition in accordance with the guidelines of the National Science Centre;
- The competition may be extended until a suitable candidate is found who meets all the requirements.
- Consent to the processing of personal data as follows : In accordance with Article 6 (1) (a) of the General Data Protection Regulation of 27 April 2016. (OJ EU L 119/1 of 4 May 2016) I consent to the processing of personal data other than: first name, (first names) and surname; parents' first names; date of birth; place of residence (mailing address); education; previous employment history, included in my job offer for the purpose of the current recruitment.";
WHERE TO APPLY?
DEADLINE: 30 Apr 2024 - 11:59 P.M. (Europe/Warsaw)
Contact
email: praca-ibmib@amu.edu.pl
Junior Scientist research position at the NanoBiomedical Center in the HORIZON-INFRA-2023-SERV-01-01 project - "Research Infrastructure Access in Nanoscience and Nanotechnology (RIANA), contract number: 101130652.
The project aims to create and improve cooperation between European research institutes and the nanoscience/technology research community, to enable inexperienced users from different scientific disciplines to benefit from advanced techniques, faster and easier access to multidisciplinary and cutting-edge scientific research and to increase innovation in nanoscience/technology. The role of Junior Scientists will be to support infrastructure users in the RIANA project and fill the gap between specialists and infrastructure users.
Requirements
Skills/Qualifications
The competition is open to individuals who meet the requirements specified in:
- Article 113 of the Law on Higher Education and Science of 20 July 2018 (Journal of Laws of 2023, item 742, Article 113 as amended)
- Appendix No. 2 to the Regulations for the allocation of funds for the implementation of tasks financed by the National Science Center in the field of research projects, as defined by the NCN Council Resolution No. 27/2022 of March 2, 2022
and who meets the following requirements:
- PhD degree in biological/ physical/ materials sciences or similar (Ph.D. degree obtained no later than 7 years before the announcement of the competition)
- documented scientific record in the area of nanotechnology
- experience in the experimental techniques used in the project: electron microscopy, nuclear magnetic resonance, and toxicity of nanomaterials.
- experience in grant realization (might be as a contractor)
- experience in the preparation of scientific publications
- proficiency in Microsoft Office environment
- fluency in English both written and spoken
Language
ENGLISH, level: Excellent
- an atmosphere of respect and cooperation
- supporting employees with disabilities
- flexible working hours
- funding for language learning
- co-financing of training and courses
- additional days off for education
- life insurance
- pension plan
- savings and investment fund
- preferential loans
- additional social benefits
- leisure-time funding
- subsidizing children's vacations
- "13th" salary
- bike racks
- scientific achievements documented by publications and their compliance with the research area competition requirements (0-20 pts);
- knowledge of the techniques and infrastructure used in the RIANA project (see pt. III) (0-20 pts);
- participation in research projects (0-5 pts);
- participation in internships (0-5 pts);
- participation in additional trainings and workshops; participation in conferences and scientific seminars (0-5 pts);
- professional development (completed courses, training, certificates) (0-5 pts).
Where to apply?
email: roksana.markiewicz@amu.edu.pl
Deadline: 30 April 2024 by 11:59 p.m. (CET - Warsaw Time)
Contact
Email: klinke@amu.edu.pl
More information on this research job offer is available here.
One Post-doc position is now available to work on mechanisms and evolution of post-copulatory mate choice in humans, in a new research group in the Institute of Human Biology and Evolution at Adam Mickiewicz University in Poznań, Poland.
The position is part of a project funded by the Polish National Science Centre: Condition-dependent mechanisms of gamete-level mate choice (postmating sexual selection) in humans. The project will test the role of immunocompetence of a male in cryptic female choice on the gamete level, to shed light on post-copulatory sexual selection in humans. The main aim of the project is to investigate how the male condition, measured as the ability to recognize pathogens, affects sperm performance, in the post-mating context in humans.
You will join a recently started research group led by Aleksandra Łukasiewicz. The application should include i.e. professional CV including scientific achievements, a list of publications, a cover letter summarizing previous work experience and future interests, contact information for two professional references, and be addressed to dr Aleksandra Łukasiewicz, a.lukasiewicz@amu.edu.pl
Requirements
Skills/Qualifications
The post-doc will use methods from experimental and evolutionary biology, molecular biology and computational genomics (phenotypic assays, wet-lab, MinION Nanopore sequencing). We seek a collogue with solid knowledge in the principles of molecular and evolutionary biology, genomics/transcriptomics, statistics, keen to work in a team and highly self-motivated. Applicant with a Ph.D (less than 7 years after graduation or close to completion) in biology, biotechnology or related fields, and proven record of productivity and publications in high-impact journals and expertise in (human) molecular genetics, molecular and cellular biology. There is opportunity to learn new skills by participation in dedicated training courses on subjects related to the project and short research visits to institutions involved with the project.
Languages
ENGLISH, level: Excellent
Additional Information
Benefits
The position is full-time and available for 36 months starting from October 2024. Salary: 9500/month (after taxes ~6500PLN)
Candidates will be selected through an open competition, the competition will be open until a suitable candidate is found who meets all the requirements
Please include in your offer: ‘’I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation).’’
Any questions? Do not hesitate to contact via email: a.lukasiewicz@amu.edu.pl
WHERE TO APPLY?
Application Deadline: 31st May 2024 by 11:59 p.m. (Central European Time/ Warsaw Time)
More information is available here,
website: